Figure 9 — Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

Research Paper|Volume 14, Issue 8|pp. 3633–3651

Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

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Figure 9.ET-1 played a critical bridging between sarcopenia and DM in elderly patients by triggering the myopathy through myocyte releases inflammation cytokines and affect the adipocyte metabolic meanwhile amplifying microenvironment injury.