Research Paper Volume 14, Issue 8 pp 3554—3568

Figure 2. Effects of intravenous injection of claudin-5 on learning and memory in APP/PS1 mice. (A) Intravenous injection of claudin-5 restored the decreased claudin-5 mRNA level in hippocampus of APP/PS1 mice, which exhibited concentration-dependent (n = 6 per group; one-way ANOVA). (B–F) The ability to search the platform (B [4 consecutive days] and C [the last day]), swim distance in the target quadrant (D), spend time in the target quadrant (E), and cross the target quadrant number of times (F) in MWM between different group mice (n = 9–10 per group; repeated measures two-way ANOVA in B; one-way ANOVA in C–F). (G) The freezing time in contextual fear conditioning test between different group mice (n = 9–10 per group; one-way ANOVA). (H) The discrimination rate in NOR test between different group mice (n = 9–10 per group; one-way ANOVA). Data show mean ± s.e.m. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.