Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD

Lina Feng; Yanping Chen; Ke Xu; Yingchao Li; Farooq Riaz; Kaikai Lu; Qian Chen; Xiaojuan Du; Litao Wu; Dan Cao; Chunyan Li; Shemin Lu; Dongmin Li

doi:doi:10.18632/aging.204011

← Back

Research Paper Volume 14, Issue 7 pp 3259—3275

Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD

Figure 7. Molecular mechanism of cholesterol-induced LAP3 upregulation in hepatocytes participated NAFLD pathogenesis. Abbreviations: CHO: cholesterol; NAFLD: nonalcoholic fatty liver disease; ROS: reactive oxygen species; LAP3: leucine aminopeptidase 3.