Research Paper
RBM3 promotes aerobic glycolysis and chemoresistance in renal clear cell carcinoma cells through regulating HK2
Figure 6. RBM3 dependent on HK2 to regulate the chemoresistance of ccRCC in vivo. (A) Schematic overview of the 5-FU/2-DG treatment and xenograft tumor model. (B) A representative image of RBM3-overexpressing OSRC-2 tumors in nude mice. (C) The volumes of the RBM3-overexpressing OSRC-2 tumors with or without 5-FU treatment. (D) The weights of the RBM3-overexpressing OSRC-2 tumors in nude mice with or without 5-FU treatment. (E) The injury was detected by hematoxylin and eosin staining. (F) The levels of RBM3 and HK2 were analyzed by immunohistochemical staining. n = 5, *p < 0.05 vs. OSRC-2; #p < 0.05 vs. OSRC-2+5FU; &p < 0.05 vs. RBM3+OSRC-2+5FU.