Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy

Haixiao Wu; Guijun Xu; Zhijun Li; Yao Xu; Yile Lin; Vladimir P. Chekhonin; Karl Peltzer; Jun Wang; Shu Li; Huiyang Li; Jin Zhang; Yuan Xue; Wenjuan Ma; Xin Wang; Chao Zhang

doi:doi:10.18632/aging.203978

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Research Paper Volume 14, Issue 12 pp 5023—5033

Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy

Figure 2. (A) Distribution and variation trends of C_MTX. The overall change trend of C_MTX at different time points after MTX chemotherapy. LP: the leukopenia group; non-LP: the non-leukopenia group. (B–F) Relationship between C_MTX levels and LP at different time points. C_MTX concentration at 6h and 24h showed the highest sensitivity and specificity for LP prediction, which were 83.8% and 58.3%, 72.1% and 83.3%, respectively.