Research Paper Volume 14, Issue 6 pp 2607—2627

Figure 3. Administration of THSG improves neurological outcomes and cognitive functions following post-TBI. (A) Evaluation of motor coordination by beam-walking test in THSG treatments after TBI. Data represented as the mean ± SEM (n = 6 per group). *, P < 0.05; **, P < 0.01 and ***, P < 0.001 TBI + Vehicle vs. TBI + THSG group. (B) Latency of beam crossing in beam-walking task. Data represented as the mean ± SEM (n = 6 per group). NS = no significantly difference between groups; ***, P < 0.001 TBI + Vehicle vs. Sham + Vehicle group; ##, P < 0.01 TBI + THSG vs. Sham + Vehicle group. (C) Neurological function measured by mNSS. Data represented as the mean ± SEM (n = 6 each group). NS = no significantly difference between TBI + THSG and Sham + Vehicle group; **, P < 0.01 and ***, P < 0.001 TBI + Vehicle vs. Sham + Vehicle group. #, P < 0.05; ##, P < 0.01 and ###, P < 0.001 TBI + THSG vs. Sham + Vehicle group. &, P < 0.05 TBI + Vehicle vs. TBI + THSG group. (D) Cognitive performance measured by the Morris water maze test. Data represented as the mean ± SEM (n = 6 per group). NS = no significantly difference between TBI + THSG and Sham + Vehicle group; *, P < 0.05 and **, P < 0.01 vs. Sham + Vehicle group. (E) Representative images showed the swimming path of the maze task without platform at day 19 following THSG treatments. The circle in the specific quadrant outlines the original position of the hidden platform. Once in the probe trial, mice were released at the opposite site (red spot) for 60 seconds. (F) Spatial memory evaluated by probe test of Morris water maze. Data represented as the mean ± SEM (n = 6 per group). NS = no significantly difference, *, P < 0.01 vs. Sham + Vehicle group. **, P < 0.01 vs. TBI + Vehicle group.