Research Paper
Circular RNA RBM33 promotes breast cancer progression by targeting miR-17-5p/CBX7 signal pathway
Figure 4. MiR-17a-5p regulates CBX7 expression in breast cancer cells. (A) Possible mRNA regulated by miR-17a-5p were selected and are presented in a Venn diagram; (B) The negative relationship between miR-17a-5p and CBX7. (C) The binding sites between CBX7 and miR-17a-5p; Luciferase activity of miR-17a-5p mimic with CBX7-WT or CBX7-MUT; (D) CBX7 expression in breast cancer cell. (E) AGO2 RIP assay; (F) Pull-down assay. (G, H) CBX7 expression regulation by miR-17a-5p mimic or circRBM33 inhibitor in breast cancer cells; Data are presented as mean ± SEM. Statistic significant differences were indicated: * P < 0.05, ** P < 0.01.