Research Paper
Circular RNA RBM33 promotes breast cancer progression by targeting miR-17-5p/CBX7 signal pathway
Figure 1. The expression of circRBM33 is upregulated in breast cancer cells. (A) The expression of circRBM33 was analyzed by qPCR in different breast cancer cells. (B–G) The MCF-7 and MDA-MB-231 cells were treated with circRBM33 siRNAs. (B) qRT-PCR was performed to assess the circRBM33 level. (C) Ki-67 staining was used to detect the cell proliferation (D) Cell cycle determined by flow cytometry analysis. (E) The cell proliferation was detected by clone formation assay. (F) The cell invasion was measured by Transwell assay. (G) The cell apoptosis was determined by TUNEL assay. Data are presented as mean ± SEM. Statistic significant differences were indicated: * P < 0.05, ** P < 0.01.