Research Paper Volume 14, Issue 5 pp 2418—2431
miRNA-29a inhibits atherosclerotic plaque formation by mediating macrophage autophagy via PI3K/AKT/mTOR pathway
Figure 6. MiR-29a overexpression inhibits AS by increasing autophagy and suppressing PI3K/AKT/mTOR pathway. (A) Western blotting reveals that the protein expressions of p-PI3K, total-PI3K, p-AKT, and p-mTOR are decreased, while those of Beclin 1 and LC3II are increased in miR-29a group in vivo. (B) Western blotting reveals that the protein expressions of p-PI3K, total-PI3K, p-AKT, p-mTOR and P62 are decreased, while those of Beclin 1 and LC3II are increased in miR-29a group in vitro.