Research Paper Volume 14, Issue 5 pp 2194—2209

Figure 5. Anti-fibrotic effect of T-MSCs-derived extracellular vesicles. In the results of morphometric analysis, the fibrotic area was significantly higher in the OVX groups than in the SHAM group. The OVX+EV group showed decreased collagen type I and TGF-βI expression. Quantitative polymerase chain reaction (qPCR) analysis of collagen I and III in the submandibular gland (A and B). The mRNA expression of collagen I and III increased in the OVX group and decreased mRNA expression of collagen I and III in the OVX+EV group, compared with that in the SHAM group (C). qPCR analysis of TGF-β1 and TGF-βII in the submandibular gland. The mRNA expression of TGF-β1 and TGF-βII increased in the OVX group and decreased mRNA expression of TGF-β1 in the OVX+EV group, compared with that in the SHAM group (D). One-way ANOVA test; ^**p < 0.01 and ^***p < 0.001 vs. SHAM. ^##p < 0.01 and ^###p < 0.001 vs. OVX.