Research Paper Volume 14, Issue 5 pp 2174—2193

Figure 4. DNA methylation and cellular senescence genes are increased and correlated in TB. A summed z-score for gene expression from each patient was assessed for pathways including DNA methylation (A), SASP (B), and OSIS (C), with all three studies demonstrating increased summed z-scores in TB patients (red box plot) as compared to controls (blue box plot). P-values from a Wilcoxon rank sum test are indicated by asterisks. (D) DNA methylation correlated with senescence pathways using Pearson correlation for GSE42834, GSE37250, and GSE39940 respectively. Abbreviations: SASP: Senescence-associated secretory phenotype; OSIS: Oxidative stress-induced senescence.