Figure 8.The ceRNA mechanism of pseudogene AK4P1 promotes PDAC progression. Genomic DNA sequence of pseudogene AK4P1 was similar to parent gene AK4. Where oncogene YAP1 is targeted by the miR375-guided RNA-induced silencing complex (miR375-RISC), leading to accelerate YAP1 degradation. And when the pseudogene-derived lncRNA is transcribed and exported to the cytoplasm, it competes for miRNA targeting and binding of RISC complexes, leading to relieve miR-375-mediated YAP1 degradation and increase YAP1 expression, which can promote PDAC progression. Abbreviations: AGO: Argonaute; RNAP II: RNA polymerase II.
