Research Paper Volume 15, Issue 6 pp 1859—1877
P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration
Figure 6. The expression of the P53/miR-34a/SIRT1 positive feedback loop in hepatocellular carcinoma patients. (F) Representative images of P53 staining in P53-wild-type patients. (G) Protein expression of the P53/miR-34a/SIRT1 positive feedback loop in P53-wild-type patient tumor tissue. (H) Quantification of hepatic miR-34a expression in P53-wild-type patient tumor tissue. (I) Representative images of P53 staining in P53-deficient patients. (J) Protein expression of the P53/miR-34a/SIRT1 positive feedback loop in P53-deficient patient tumor tissue. (K) Quantification of hepatic miR-34a expression in P53-deficient patient tumor tissue. C: liver cancer tissue N: adjacent normal liver tissue (***, p<0.001).