Research Paper Volume 14, Issue 4 pp 1812—1821
Qi Ling decreases paclitaxel resistance in the human prostate cancer by reversing tumor-associated macrophages function
Figure 5. Qi Ling serum resensitized paclitaxel-resistant prostate cancer cells to paclitaxel via IL-6/STAT3 signaling in TAMs. In the same co-culture system above: TAMs were treated with PBS+vehicle, Qi Ling+vehicle or Qi Ling+IL-6. (A and B) MTT assay showed viability of DU145-TxR and PC-3-TxR cells of each group exposed with indicated concentrations of paclitaxel for 24 h. (C) IC50 values of DU145-TxR and PC-3-TxR cells of each group were determined from the viability versus paclitaxel concentration curves. The data represent the mean ± SD. **p < 0.01; ***p < 0.001 determined by two-way ANOVA followed a post hoc test for panels (A and B), one-way ANOVA followed a post hoc test for panel (C).