Figure 9 — Long non-coding RNA Linc00205 promotes hepatoblastoma progression through regulating microRNA-154-3p/Rho-associated coiled-coil Kinase 1 axis via mitogen-activated protein kinase signaling

Research Paper|Volume 14, Issue 4|pp. 1782–1796

Long non-coding RNA Linc00205 promotes hepatoblastoma progression through regulating microRNA-154-3p/Rho-associated coiled-coil Kinase 1 axis via mitogen-activated protein kinase signaling

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Figure 9.Linc00205 affects the p38 MAPK signaling pathway by interacting with ROCK1, and further affects EMT pathway-related protein (vimentin), apoptosis pathway protein (Bax) and proliferation pathway protein (cyclinD1) and the effects are regulated by miR-154-3p and ROCK1. Western blot assays for ROCK1, p-p38MAPK, p38MAPK, Twist, Vimentin, Bax and CyclinD1 protein expression in HepG2 cells transfected in different groups.