Research Paper Volume 14, Issue 3 pp 1307—1320

Figure 5. Inhibiting effect of miR-29 on cell migration in UtLMCs and EMT in endometrial epithelial cells. (A) miR-29 inhibited MMP-2 and MMP-9 in vitro compared with the NC control, and miR-29 inhibitors promoted the protein expression of MMP-2 and MMP-9 in vitro compared with the anti-NC control. (B) miR-29 increased the E-cadherin and suppressed the N-cadherin, snail, vimentin expression vs. NC control, and miR-29 inhibitors decreased E-cadherin and increased N-cadherin, snail, vimentin expression in endometrial epithelial cells tested by western blot. (C) miR-29 suppressed cell migration in UtLMCs in vitro compared with the NC control, and MiR-29 inhibitors promoted cell migration in UtLMCs in vitro compared with the anti-NC control. Data are presented as mean ± SE (*P < 0.05, **P < 0.01). UtLMCs: Uterine leiomyoma cells; NC: negative control; MMP: matrix metalloproteinases.