Figure 3. White matter hyperintensities (WMHs) depicted as white, well-defined lesions or confluent areas in white matter on fluid-attenuated inversion recovery (FLAIR) scans in three participants during the 5-year intervention period. The yellow arrows point to areas with growing WMH lesions (Subject 1) or a new lesion (Subject 2). The lower row shows the manually delineated WMHs (red outline) across 4 out of 176 slices in one participant.