Research Paper Volume 14, Issue 1 pp 462—476

Figure 5. Atorvastatin attenuates the effects of LPS on inducing neuroinflammation. Total proteins were extracted from LPS-induced BV2 cells treated with atorvastatin. (A) IL-1β, TNF-α and IL-6; (B) NLRP3 and caspase-1; (C) TLR4 and MyD88 protein expression levels are revealed by western blotting analysis. GAPDH served as an internal control. The band densities were measured by Image J to estimate protein quantities. The results represent the mean ± SD for the repeated experiments. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 vs. vehicle treatment. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001 vs. LPS treatment.