Research Paper Volume 14, Issue 1 pp 297—315

Figure 1. TIMP-2 is elevated in 5-Fu resistant CRC patients and predicts clinical outcomes. (A) Relative cytokine expression levels in the serum of 5-Fu sensitive and resistant patients. Patient details are shown in Table 1. Sen, sensitive patients. Res, resistant patients. (B) Differences in TIMP-2 protein expression levels in non-resistant (n = 9) and resistant patients (n = 9) with colorectal cancer. Patient details are shown in Table 2. Sen, sensitive patients. Res, resistant patients. (C) 6-year OS Kaplan–Meier survival curves for 84 colorectal cancer patients, differential grouping based on TIMP-2 expression (36.6 ng/ml) in serum. Table 3 shows patient information. (D) 6-year DFS Kaplan–Meier survival curves for 84 colorectal cancer patients, differential grouping based on TIMP-2 expression (36.6 ng/ml) in serum. Table 3 shows patient information. (A, B) ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 by unpaired Student’s t-test. (C, D) ^*p < 0.05 by logrank (Mantel-Cox), HRs are shown in the figures.