Research Paper Volume 13, Issue 24 pp 25886—25902
Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice
Figure 4. Loxl1 knockout mice mimic the phenotype and functional changes of clinical POP. (A) The gross pictures showed there was a pelvic organ prolapse phenotype in Loxl1 knockout mice. (B) The simulated image of pelvic floor support test. (C) The pelvic floor support test showed the different mechanical property of the pelvic floor from Loxl1 knockout mice and the wild type mice, horizontal axis represent the displacement (mm) and vertical axis represent the load (N), n = 4. (D, E) the failure force (D) and Young’s modulus (E) of pelvic floor showing that the values from the WT group were higher than the loxl1 knockout group, n = 4. (F–H) LPP was performed to test the urinary function, there were decreased average LPP-peak value (F) and decreased lowest LPP-peak value (G) while there was an increased Inter-Quartile Range (IQR) of the average LPP-peak value (H) in the Loxl1 knockout mice.