Research Paper Volume 13, Issue 24 pp 25859—25885
Identification and functional analysis of lncRNAs and mRNAs between tumorigenesis and metastasis in CRC
Figure 3. Functional analysis of lncRNAs in CRC tumorigenesis. (A) GO enrichment showed differentially expressed lncRNA associated biological processes (top 10). (B) KEGG pathway analysis showed differentially expressed lncRNAs associated signal pathways (top 10). (C) Hallmark Gene Sets analysis showed differentially expressed lncRNAs associated biological processes of diseases and cancer (top 10). (D) GO terms network. Each term is represented by a circle node, where its size is proportional to the number of input genes fall into that term, and its color represent its cluster identity. (E) The top MCODE network for differentially expressed lncRNAs associated mRNAs. (F) Overall survival for patients in TCGA-COAD according to the TOP2A expression level. (G) Overall survival for patients in TCGA-COAD according to the CHEK1 expression level.