Research Paper Volume 13, Issue 23 pp 25325—25341
Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression
Figure 7. The effects of Art treatment and silencing β-catenin expression on apoptosis and ROS and SOD production in skin tissues of mice. (A, B) TUNEL staining of skin tissues for assessing cell apoptosis in control group, UV + sh-NC group, UV + sh-β-catenin group, UV + sh-NC + Art group and UV + sh-β-catenin + Art group. Scale bar: 100 μm. Magnification: 200×. (C) Detection of SOD levels in skin tissues of mice from each group. (D, E) Immunofluorescence for intracellular ROS production in skin tissues of mice from each group. Scale bar: 100 μm. Magnification: 200×. Ns: not significant; *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.