Figure 5.A schematic diagram of the polyol pathway in COC and the mechanism of the effect of sorbitol accumulation on oocyte quality (in vivo or in vitro) of aged mice. Abbreviations: PPP: pentose phosphate pathway; HBP: hexosamine biosynthesis pathway; TCA: tricarboxylic acid cycle; OXPHOS: oxidative phosphorylation; NADPH: nicotinamide adenine dinucleotide phosphate (reduced form); PRPP: 5-phosphoribosyl-1-pyrophosphate; GSSG: glutathione (oxidized form); GSH: glutathione (reduced form); ROS: reactive oxygen species.
