The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice

Qiyun Zhou; Zhiqiang Guan; Shengfu Liu; Yanjiao Xuan; Gang Han; Hua Chen; Xiao Jin; Kun Tao; Zhiyuan Guan

doi:doi:10.18632/aging.203729

← Back

Research Paper Volume 14, Issue 1 pp 272—285

The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice

Figure 6. The effect of metformin and alendronate on serum biomarker, pathology and biomechanics. (A) mineral apposition rate (MAR). (B) bone formation rate per bone surface (BFR/BS). (C) maximum load. (D) stiffness. (E) ultimate displacement. (F) energy absorption. (G) serum OCN. (H) Serum TRAP 5b. (I) Serum CTX-1. (J) Serum GLP-1.