Priority Research Paper Volume 13, Issue 19 pp 22629—22648
Article has an altmetric score of 153

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

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Figure 4. EGCG and ECG mediate lifespan extension dependent on PMK-1/p38 MAPK, SKN-1/NRF2, and DAF-16/FOXO. The representative outcome of lifespan assay of pmk-1 mutants treated with 0.1% DMSO versus 2.5 μM EGCG (A) or 2.5 μM ECG. (B) The representative outcome of lifespan assay of skn-1 mutants treated with 0.1% DMSO versus 2.5 μM EGCG (C) or 2.5 μM ECG. (D) The representative outcome of lifespan assay of daf-16 mutants treated with 0.1% DMSO versus 2.5 μM EGCG (E) or 2.5 μM ECG. (F) P-values are as indicated in the graphs. See Table 1 for corresponding detailed data and statistical analyses of lifespan assays.