Priority Research Paper Volume 13, Issue 19 pp 22629—22648

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

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Figure 1. Increased lifespan, locomotion activity, and stress resistance after EGCG and ECG treatment. The representative outcome of lifespan assay of N2 wild-type nematodes in the presence of 2.5 μM EGCG versus DMSO. (A) The representative outcome of lifespan assay of N2 wild-type nematodes in the presence of 2.5 μM ECG versus control. (B) Locomotion quantification for N2 wild-type nematodes after 7 days exposure to DMSO, 2.5 μM EGCG, or 2.5 μM ECG. (C) The representative outcome of the survival analysis (h) of N2 nematodes in 50 mM paraquat solution after 7 days of pretreatment with EGCG (D) or ECG (E) in comparison to worms pretreated with DMSO. P-values are as indicated in the graphs. See Table 1 and Table 2 for corresponding detailed data and statistical analyses of lifespan assays and of paraquat stress assay, respectively.