Research Paper

Figure 4. LINC01224 regulates the growth of gastric cancer cells in vivo. Nude mice were subcutaneously transplanted with AGS-Luc2 cells transfected with LINC01224 shRNA or control shRNA. 16 days later, mice were sacrificed. (A) IVIS images showed the effect of knockdown of LINC01224 on the growth of xenografts in nude mice. Mice were imaged for bioluminescence. (B) The left image shows the morphology of the xenograft tumor after 16 days of implantation. The middle chart shows the change in graft volume every 3 days after injection. The right chart shows the weight of the transplanted tumor after 16 days of injection. (C) Ki-67 staining of transplanted tumor after knockdown of LINC01224. Scale bars = 50 μm. (D) The effect of shRNA on LINC01224 mRNA expression of xenograft tumor in nude mice was detected by qRT-PCR.