Figure 4. Validation of the prognostic signature. Kaplan-Meier plots of overall survival between high- and low-risk patients in the (A) internal validation cohort, (B) entire GSE31312 cohort, and (C) external validation cohort. Univariate Cox regression analyses in the (D) internal validation cohort, (E) entire GSE31312 cohort, and (F) external validation cohort. Multivariate Cox regression analysis in the (G) internal validation cohort, (H) entire GSE31312 cohort, and (I) external validation cohort.