Research Paper Volume 14, Issue 11 pp 4699—4713
Hsa_circ_0063804 enhances ovarian cancer cells proliferation and resistance to cisplatin by targeting miR-1276/CLU axis
Figure 6. Circ_0063804 silencing inhibited OC cells growth and resistance to cisplatin in vivo. (A) Circ_0063804 silencing and cisplatin decreased xenograft tumor volume. (B) The xenograft tumor in nude mice of each group was presented. (C) Circ_0063804 silencing and cisplatin decreased xenograft tumor weight. (D) Circ_0063804 silencing and cisplatin reduced Ki76 expression in xenograft tumor. (E) Circ_0063804 silencing and cisplatin reduced CLU mRNA expression in xenograft tumor. (F) Circ_0063804 silencing and cisplatin increased miR-1276 expression in xenograft tumor. * P < 0.05. ** P < 0.01. OC: ovarian cancer.