Research Paper Volume 14, Issue 11 pp 4699—4713
Hsa_circ_0063804 enhances ovarian cancer cells proliferation and resistance to cisplatin by targeting miR-1276/CLU axis
Figure 5. Circ_0063804 promoted OC development in vitro by enhancing CLU expression via sponging miR-1276. (A) circ_0063804 could enhance CLU expression via sponging miR-1276. (B, C) CCK-8 assay and colony formation assay revealed that, circ_0063804 promoted OVCAR3 cells proliferation through promoting CLU expression via sponging miR-1276. (D) circ_0063804 inhibited OVCAR3 cells apoptosis by enhancing CLU expression via sponging miR-1276. (E) circ_0063804 elevated the IC50 of OVCAR3 cells by enhancing CLU expression via sponging miR-1276. (F) circ_0063804 enhanced CLU, p-gp and PARP proteins expression, and weakened c-PARP protein expression through promoting CLU expression via sponging miR-1276. ** P < 0.01. CCK-8: cell counting kit-8. OC: ovarian cancer.