Figure 5.Effect of RUFY3 down-regulation or up-regulation on HCC cell growth and metastasis in vivo. (A) Effect of RUFY3 down-regulation or up-regulation on HCC cell subcutaneous xenograft growth in nude mice. Tumor mass and tumor volume are shown in the panels. (B) IHC analysis of RUFY3 and Ki-67 expression levels in xenograft tumor samples. (C) Effect of RUFY3 down-regulation or up-regulation on the metastasis of HCC cell in vivo. (D) Western blot analyses of the expression levels of RUFY3, E-cadherin, and N-cadherin in the lung metastatic nodules. *P<0.05.
