UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma

Minfen Zhang; Hui Chen; Ping Qin; Tonghui Cai; Lingjun Li; Ruichao Chen; Shaoyan Liu; Hui Chen; Wanrun Lin; Hao Chen; Amanda L. Strickland; Hanzhen Xiong; Qingping Jiang

doi:doi:10.18632/aging.203421

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Research Paper Volume 13, Issue 17 pp 21202—21215

UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma

Figure 1. High expression of UPF1 in EEC: (A, B) 28 (66.7%) of 42 EEC patients had high expression of UPF1. In 5 of 42 cases (11.9%), the expression level was lower than normal tissues. Of the 42 cases, 9 had no significant difference with normal tissues. (C) Overall analysis the high expression of UPF1 in EEC is of great significance. (D) Immunohistochemical results showed that the positive rate of 17 (80.95%) of the 21 patients (T) was higher than that of the normal control group (N). The positive rate of 4 cases (T) (19.05%) was lower than that of the normal control group (N)(NIKON, 200X). (E) Scoring of immunohistochemistry. Data was represented as the mean +/- SEM.*P<0.05, **P<0.01, ***P<0.001.