Research Paper Volume 13, Issue 15 pp 19165—19185
Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging
Figure 10. Schematic summary of the effects of aging on endothelial function in wild-type (WT) mice (A) and endothelium-specific amyloid precursor protein-deficient (eAPP−/−) mice (B). Please note that expression of APP is increased in aged wild-type mice (A) but not in aged eAPP−/− mice (B) aortas. ↑ = increase; ↓ = decrease; ↔ = no change; eNOS = endothelial nitric oxide synthase; ROS = reactive oxygen species; COX2 = cyclooxygenase 2; TXB2 = thromboxane B2; PGE2 = prostaglandin E2; ACh = acetylcholine.