Research Paper Volume 13, Issue 14 pp 19013—19027
Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ
Figure 4. Levels of apoptosis were elevated in hippocampus of diabetic rats. “a” in (A) showed elevated CML levels in hippocampus of diabetic rats, compared with control rats (P<0.05). “a” in (B) showed decreased GLP-1 levels in hippocampus of diabetic rats, compared with control rats (P<0.05). Results in (C) showed increased apoptosis in hippocampus of diabetic rats, compared with control rats. Results in (D) showed down-regulated PPAR-γ and GLP-1R in hippocampus of diabetic rats, compared with control rats. (E) Showed the western blotting results of bcl2, bax, GLP-1R and PPAR-γ. “a” of (F) showed down-regulated bcl2, GLP-1R and PPAR-γ levels and up-regulated bax levels in hippocampus of diabetic rats, compared with control rats (all P<0.05). Data are represented as mean ± SD; n=4 per group for results of ELISA. n=3 per group for results of western blotting.