Research Paper Volume 13, Issue 14 pp 18515—18526
Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion
Figure 1. Agomelatine reduced Ang II-induced the expression of Ang II type 1 receptor (AT1 receptor) in HUVECs. HUVECs were treated with Ang II (1 μM) with or without agomelatine (10, 20 μM) for 24 h. mRNA of AT1 receptor (##, **, &&, P<0.01 vs. vehicle control, Ang II, Ang II+ 10 μM agomelatine group).