Research Paper Volume 13, Issue 15 pp 19293—19305

Figure 8. Apremilast inhibited IL-1α-induced activation of NF-kB in ESCs. Cells were stimulated with 5 ng/mL IL-1α in the presence or absence of 1.5 or 3 μM Apremilast for 6 hours. (A). Levels of p-NF-κB p65; (B). Luciferase activity of NF-κB (^****P < 0.0005 vs. vehicle group; ^#, ^##, P < 0.05, 0.01 vs. IL-1α treatment group, N = 5–6).