Cell landscape atlas for patients with chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy constructed using single-cell RNA sequencing

Ran Miao; Xingbei Dong; Juanni Gong; Yidan Li; Xiaojuan Guo; Jianfeng Wang; Qiang Huang; Ying Wang; Jifeng Li; Suqiao Yang; Tuguang Kuang; Jun Wan; Min Liu; Zhenguo Zhai; Jiuchang Zhong; Yuanhua Yang

doi:doi:10.18632/aging.203168

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Research Paper Volume 13, Issue 12 pp 16485—16499

Cell landscape atlas for patients with chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy constructed using single-cell RNA sequencing

Figure 6. Characterization of cancer stem cells and CRISPLD2+ cells in pulmonary endarterectomized tissues of CTEPH patients. (A) Violin plot illustrating cancer stem cell marker genes, including CTNNB1 and TP53. (B) GO enrichment analysis of cancer stem cell marker genes. (C) Violin plot showing the CRISPLD2 marker of CRISPLD2+ cells. Abbreviations: CTEPH: chronic thromboembolic pulmonary hypertension; CRISPLD2: cysteine-rich secretory protein LCCL domain containing 2; GO: Gene ontology.