Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer

Jingjing Wu; Wen Xu; Lina Ma; Jiayu Sheng; Meina Ye; Hao Chen; Yuzhu Zhang; Bing Wang; Mingjuan Liao; Tian Meng; Yue Zhou; Hongfeng Chen

doi:doi:10.18632/aging.203156

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Research Paper Volume 13, Issue 14 pp 18191—18222

Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer

Figure 8. The mechanism map illustrated that lncRNA AFAP1-AS1 promoted triple-negative breast cancer (TNBC) progression and chemo-resistance by disturbing the interaction of miR-195 with Raf-1 and that of miR-545 with CDK4. However, formononetin antagonized TNBC malignancy by lessening the effect of lncRNA AFAP1-AS1-guided miR-545/CDK4 axis and miR-195/Raf-1 axis on TNBC cells.