Figure 2 — Systemic NF-κB-mediated inflammation promotes an aging phenotype in skeletal stem/progenitor cells

Research Paper|Volume 13, Issue 10|pp. 13421–13429

Systemic NF-κB-mediated inflammation promotes an aging phenotype in skeletal stem/progenitor cells

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Figure 2.SSPC frequency declines in response to increased NF-κB-mediated inflammation. (A) SSPCs isolated from parabiosed animals six weeks post-surgery revealed that exposure to increased inflammation results in decreased SSPC number as revealed by colony forming unit (CFU) assays. (B) Nfkb1^-/-^WT and WT^Nfkb1-/- SSPCs gave rise to significantly fewer colonies than those isolated from the WT^WT parabionts as revealed by CFU-f efficiency (n=3, *P < 0.05).