Research Paper Volume 13, Issue 13 pp 17155—17176

Figure 7. Targeted knockdown of EMS or WTAP significantly enhanced the therapeutic effects of DDP in tumor eradication. Nude mice were inoculated with EMS-silenced or WTAP-silenced ECA-109 cells and treated with DDP. Tumor growth curves (A), tumor weight (B), cell proliferation (C), and apoptosis (D) of tumor tissues, as well as the RNA/transcript levels of EMS, miR-758-3p, and WTAP (E), the protein level of WTAP (F), and mRNA levels of mouse IL-10 (G) in tumor tissues are shown. For tumor volume comparisons (A), sh-NC+Vehicle, sh-EMS+Vehicle, or sh-WTAP+Vehicle group was compared with their corresponding DDP treatment group, respectively. n=5 mice in each group, and representative data are from at least 5 experiments with similar results. n=5 for each group.