Research Paper Volume 13, Issue 12 pp 15964—15989

Figure 11. Time-dependent effects of AS on body weight of AOM/DSS-treated ICR mice. Mice were injected intraperitoneally with a single dose (15 mg/kg) of AOM (the first week) followed by 3 times of 2% DSS given in the drinking water every two days (the second week). AS (150 and 300 mg/kg) was given oral administration every two days and sacrificed on 15 weeks after CAC induction. Body weight was recorded for every week and the values were expressed as mean ± SEM (n = 9~13) mice/group. Statistical significance was defined as ^*p < 0.05; ^**p < 0.01; ^***p < 0.001 compared with control. ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 compared with AOM/DSS-treated cells.