Figure 3 — Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

Research Paper|Volume 13, Issue 9|pp. 13264–13286

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

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Figure 3.circRNA_102481 is mainly secreted via exosomes. (A, B) circRNA_102481 was unregulated in EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827). (C, D) circRNA_102481 was significantly up-regulated in exosomes of EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827).