Figure 3. circRNA_102481 is mainly secreted via exosomes. (A, B) circRNA_102481 was unregulated in EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827). (C, D) circRNA_102481 was significantly up-regulated in exosomes of EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827).