Research Paper Volume 13, Issue 8 pp 10891—10919

Figure 4. Analysis of basic metabolic parameters in blood of fed mice. (A–C) Plasma insulin measured in NCD-fed (A), HSD-fed (B) and HFD-fed (C) mice at baseline (week 0) and after 4, 8, 12, 16, and 20 weeks of diet. Corticosterone levels (D) and NEFA levels (E) measured in blood plasma obtained upon sacrifice after 20 weeks of diet. Data are represented as box (25^th to 75^th percentile) with median and whiskers from minimum to maximum. Black asterisks indicate significant differences between groups (*: p<0.05; **: p<0.01; ***: p<0.001), gray asterisk indicates a statistical trend towards significance (p<0.1) according to Tukey post-hoc test of repeated measures ANOVA (A–C) and nonparametric multiple contrast Tukey-type test (D, E). n_{NCD WT}=15, n_{NCD APP23}=9, n_{HSD WT}=10, n_{HSD APP23}=14, n_{HFD WT}=10, n_{HFD APP23}=10.