Research Paper Volume 13, Issue 9 pp 12607—12630

Figure 4. Prediction of miRNA-target interactions and ceRNA pairs, and construction of a circRNA-miRNA-mRNA ceRNA regulatory network. (A) MiRNA-circRNA interactions were filtered based on the miRNA-circRNA correlation coefficients and the miRNA-circRNA target pairs. (B) MiRNA-mRNA interactions were filtered based on the miRNA-mRNA correlation coefficients and the miRNA-mRNA target pairs. (C) Filtered miRNA-target interactions were integrated into circRNA-mRNA pairs (ceRNA pairs) based on shared miRNAs. CeRNA pairs were further filtered based on the ceRNA scores and the mRNA-circRNA correlation coefficients. (D) The ceRNA network. Yellow V-shaped nodes represent DECs, red rectangular nodes represent DEMis, and blue circular nodes represent DEMs. Larger nodes in the ceRNA network represent genes with higher degrees of connectivity.