Figure 7.Mechanism pattern diagram of hepcidin overexpression to improve bone metabolism. Hepcidin overexpression in the model mice liver (1) reduces estrogen deficiency-induced bone loss (2), through reducing iron content (3), decreasing mitochondrial respiration (4) and ROS production (5), suppressing PGC-1β expression (6), inhibiting mitochondrial biogenesis (7), and depressing the function of osteoclasts (8).
