Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Yi Zhuo; Wei Chen; Wenshui Li; Yan Huang; Da Duan; Lite Ge; Jialin He; Jianyang Liu; Zhiping Hu; Ming Lu

doi:doi:10.18632/aging.202807

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Research Paper Volume 13, Issue 8 pp 11234—11256

Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Figure 5. IhOM-MSCs transplantation reduces the damaged area of the infarct cortex and improves motor function after ischemic stroke. (A) The diagram shows the time course of the various experiments in this study. (B) TTC was used staining to determine the therapeutic effect of IhOM-MSCs on the infarct cortex. (C) The neurological deficits of rats were evaluated before and after cell transplantation using the mNSS scale. (D) The improvement of passive motor functions was evaluated in rats before and after cell transplantation by rota-rod treadmills. (OM-MSCs were replaced by MSCs in the figure. All data are presented as the mean value ± SD. *p<0.05, **p<0.01).