Figure 8. Association of ITIH1 expression with tumor microenvironment factors. Correlation between ITIH1 expression and immune infiltration of CD8+ T cells (A) and cancer-associated fibroblasts (CAFs) (B) across different cancers in TCGA. (C) Correlation between ITIH1 expression and T cell exclusion signatures, including FAP+ CAFs, myeloid-derived suppressor cells (MDSC), and tumor-associated M2 macrophages (TAM M2) in the TIDE (Tumor Immune Dysfunction and Exclusion) database.