Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial–mesenchymal transition and stem-like reprogram

Cihui Yan; Jingjing Chang; Xinmiao Song; Ying Qi; Zhenyu Ji; Ting Liu; Wenwen Yu; Feng Wei; Lili Yang; Xiubao Ren

doi:doi:10.18632/aging.202732

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Research Paper Volume 13, Issue 7 pp 9780—9800

Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial–mesenchymal transition and stem-like reprogram

Figure 6. Tumor growth and metastasis promoted by LC-MSCs. 10⁶ each of A549.Luc cells and LC-MSCs or TF-MSCs were co-implanted subcutaneously into female Balb/c nude mice. Tumor growth was monitored by bioluminescence imaging. (A) Bioluminescence images at the indicated time. (B) Total bioluminescence of tumors at indicated time. (C) Bioluminescence images of sentinel lymph nodes from sacrificed mice at the end of experiment. (D) Immunohistochemistry test for Ki67 in tumor tissues. *, P < 0.05 were considered to be statistically significant.