Figure 6 — Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERα

Research Paper|Volume 13, Issue 8|pp. 11026–11042

Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERα

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Figure 6.Effects of calycosin on xenograft tumor growth and the expression levels of RP11-65M17.3, ERα and BRIP1 in tumor tissue. (A–C) Nude mice bearing MCF-7-xenografted were treated for 20 days with calycosin (0 or 8 mg/kg) and 20 μg/kg E₂. The tumor volume and tumor weight of the MCF-7 xenografts were measured (n = 6). (D) The tumor samples were subjected to IHC staining for BRIP1. (E–G) The mRNA expression levels of RP11-65M17.3, ERα and BRIP1 in the tumor tissues were determined using qRT-PCR, and β-actin served as the control. Representative data from three independent experiments are shown. *p < 0.05 vs. control; ^#p < 0.05 vs. 8 mg/kg calycosin.