Figure 2. Knockdown of p16 at later timepoints decreases IL6 and CXCL8 expression without bypassing oncogene-induced senescence. IMR90s expressing BRAFV600E alone or in combination with shRNAs targeting p16 (shp16 hairpin #1 and #2). An empty pBabe retroviral vector and a shRNA targeting GFP lentiviral vector were used as controls. See